Who will win: Jaguars or 49ers?

Niners Roll Into Week 4 with Injury Concerns, Jaguars Eye Upset

The Jacksonville Jaguars (2‑1) travel to take on the undefeated San Francisco 49ers (3‑0) in a matchup that has been impacted by key injuries on the Niners—most notably Nick Bosa’s season‑ending ACL tear, plus uncertainty at QB and other skill positions. The odds favor San Francisco by about 3 to 3.5 points, and the total is set in the mid‑40s. Jacksonville’s defense has been surprising so far, and they may have a chance to keep this tight if they exploit the 49ers’ vulnerabilities. Can Brock Purdy (if healthy) put up enough to maintain the edge, or will Jacksonville pull off a close road win?

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  • Jacksonville Jaguars
  • San Francisco 49ers

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