Who will win in Week 6: San Francisco 49ers or Tampa Bay Buccaneers?

49ers Look to Stay Perfect as They Host Buccaneers in Week 6

The San Francisco 49ers enter Week 6 of the NFL season undefeated at 5–0, hosting the 1–4 Tampa Bay Buccaneers. San Francisco's dominant performances on both sides of the ball have made them heavy favorites, with Christian McCaffrey, Deebo Samuel, and Brock Purdy leading the offense. Tampa Bay has struggled to generate consistent offense, and faces a tough task against the 49ers' top-ranked defense. The game is scheduled for Sunday, October 12, and will be played at Levi's Stadium. Oddsmakers have the 49ers favored by 10.5 points with a total line around 44. This poll will close the night before kickoff, giving fans time to predict the winner before the action begins.

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  • San Francisco 49ers
  • Tampa Bay Buccaneers

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